Title:Postdoc Research Associate- Ophthalmology and Visual Sciences (Job ID #140092)Department:Medicine/Ophthalmology and Visual SciencesCategory:Postdoc Res AssocLocation:ChicagoClose Date:01/08/2021Description:
The Department of Ophthalmology and Visual Sciences at the University of Illinois at Chicago is seeking to fill a Postdoctoral Research Associate position in Vascular Biology.Duties:
A postdoctoral position is available immediately for a project investigating the transcriptional mechanism by which VEGF/anti-VEGF control the endothelial cell barrier. This project’s working hypothesis is that anti-VEGF’s therapeutic benefit depends on reversing VEGF-induced changes in expression of genes, which are responsible for the chronic increase in permeability of retinal blood vessels. We test this hypothesis using a two-step approach. First, we identify anti-VEGF-regulated genes in the endothelium of pathological blood vessels isolated from eyes of patients with diabetic retinopathy. Second, we determine if such genes are regulated by VEGF, if they govern the endothelial cell barrier, and whether such genes are necessary for anti-VEGF to reclose the barrier that has been breached with VEGF. This NIH-supported position is an one year appointment, with the possibility of a second or third year extension based on research performance.Qualifications:
Candidates must have a Ph.D. in biochemistry, molecular biology, cell biology, bioinformatics, systems biology and/or related fields. Experience with bioinformatics, cell culture and molecular biology is required. Applicants should send a cover letter, their curriculum vitae, a brief description of their research interests, and the names/contact information of three references to Andrius Kazlauskas; [email protected].