Location:Heidelberg, Germany
Staff Category:Postdoctoral Fellow
Contract Duration:2 years
Closing Date:7 January 2021
Reference Number:HD01878

The Savitski group at EMBL Heidelberg is seeking a postdoc (2 years funding with an opportunity for extension by another year) with a proteomics/biochemistry background to work in collaboration with Marcus Bantscheff group at GSK/Cellzome on development of functional proteomics methods for the systematic in situ identification of protein interactions and function. In particular, the candidate will work on combining Thermal Proteome Profiling (TPP) and proximity tagging by biotinylation (BioID) to achieve unprecedented characterization of protein function and interactions in situ across the proteome. These methods will then be applied to deconvolute the functional roles of small proteins and other non-canonical translation products in the context of genetic variants with disease associations.  

Your role

  • Setting up functional proteomics strategies for in situ identification of protein interactions and function, in particular, setting up the BioID pipeline.
  • Exploring best strategies for combining BioID and TPP on an experimental and computational level.
  • Designing experiments to investigate the functional relevance of small proteins.
  • Dissemination of research results in scientific publications and presentations at international conferences.

You have

  • PhD (or equivalent qualification) proteomics/biochemistry.
  • Familiarity with working with large datasets.
  • A keen interest in biological applications.
  • You should be able to work independently, be very well organized, reliable and enjoy working in an international team within a highly collaborative atmosphere.
  • Excellent communication and presentation skills, a high level of motivation and fluency in English are required.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises from a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family and the availability of an excellent child care facility on campus.

What else you need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1800 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome. Our other missions are to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research. The working language of the institute is English.



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